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Target
VIM-2 type metallo-beta-lactamase
Ligand
BDBM50560033
Substrate
n/a
Meas. Tech.
ChEMBL_2071126 (CHEMBL4726660)
IC50
23000±n/a nM
Citation
 Muhammad, Z; Skagseth, S; Boomgaren, M; Akhter, S; Fröhlich, C; Ismael, A; Christopeit, T; Bayer, A; Leiros, HS Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-?-lactamases. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
VIM-2 type metallo-beta-lactamase
Synonyms:
VIM-2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28318.00
Organism:
Pseudomonas aeruginosa
Description:
n/a
Residue:
266
Sequence:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
  
Inhibitor
Name:
BDBM50560033
Synonyms:
CHEMBL4753298
Type:
Small organic molecule
Emp. Form.:
C12H13IN4O4S
Mol. Mass.:
436.225
SMILES:
CC(=O)OCc1nn[nH]c1CNS(=O)(=O)c1ccc(I)cc1
Structure:
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