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Target
STE20/SPS1-related proline-alanine-rich protein kinase
Ligand
BDBM50560444
Substrate
n/a
Meas. Tech.
ChEMBL_2072182 (CHEMBL4727716)
IC50
3200±n/a nM
Citation
 Fujii, S; Kikuchi, E; Watanabe, Y; Suzuyama, H; Ishigami-Yuasa, M; Mori, T; Isobe, K; Uchida, S; Kagechika, H Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
STE20/SPS1-related proline-alanine-rich protein kinase
Synonyms:
DCHT | SPAK | STK39 | STK39_HUMAN | Serine/threonine-protein kinase 39 | Ste-20-related kinase
Type:
PROTEIN
Mol. Mass.:
59471.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774551
Residue:
545
Sequence:
MAEPSGSPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVLRLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQLSVS
  
Inhibitor
Name:
BDBM50560444
Synonyms:
CHEMBL4796271
Type:
Small organic molecule
Emp. Form.:
C25H19BrClNO4
Mol. Mass.:
512.78
SMILES:
COc1cccc(OC)c1C(=O)Nc1ccc(Oc2ccc3ccccc3c2Br)c(Cl)c1
Structure:
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