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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50560863
Substrate
n/a
Meas. Tech.
ChEMBL_2073756 (CHEMBL4729290)
Ki
>10000±n/a nM
Citation
 Lu, X; Liu, YC; Orvig, C; Liang, H; Chen, ZF Discovery of a Copper-Based Mcl-1 Inhibitor as an Effective Antitumor Agent. J Med Chem 63:9154-9167 (2020) [PubMed]  Article 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50560863
Synonyms:
CHEMBL4743955
Type:
Small organic molecule
Emp. Form.:
C18H15N3
Mol. Mass.:
273.3318
SMILES:
CCn1c2ccccc2c2ccnc(-c3ccccn3)c12
Structure:
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