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Target
von Hippel-Lindau disease tumor suppressor
Ligand
BDBM50561318
Substrate
n/a
Meas. Tech.
ChEMBL_2074780 (CHEMBL4730314)
Kd
800±n/a nM
Citation
 Klein, VG; Townsend, CE; Testa, A; Zengerle, M; Maniaci, C; Hughes, SJ; Chan, KH; Ciulli, A; Lokey, RS Understanding and Improving the Membrane Permeability of VH032-Based PROTACs. ACS Med Chem Lett 11:1732-1738 (2020) [PubMed]  Article 
Target
Name:
von Hippel-Lindau disease tumor suppressor
Synonyms:
Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL
Type:
Protein
Mol. Mass.:
24136.87
Organism:
Homo sapiens (Human)
Description:
P40337
Residue:
213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
  
Inhibitor
Name:
BDBM50561318
Synonyms:
CHEMBL4782620
Type:
Small organic molecule
Emp. Form.:
C30H35N3O5S
Mol. Mass.:
549.681
SMILES:
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](OC(=O)Cc2ccccc2)C(C)(C)C)cc1 |r|
Structure:
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