Reaction Details Report a problem with these data
Target
Ornithine aminotransferase, mitochondrial
Ligand
BDBM50561615
Substrate
n/a
Meas. Tech.
ChEMBL_2075537 (CHEMBL4731071)
Ki
250000±n/a nM
Citation
 Shen, S; Doubleday, PF; Weerawarna, PM; Zhu, W; Kelleher, NL; Silverman, RB Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase. ACS Med Chem Lett 11:1949-1955 (2020) [PubMed]  Article 
Target
Name:
Ornithine aminotransferase, mitochondrial
Synonyms:
OAT | OAT_HUMAN | Ornithine aminotransferase, hepatic form | Ornithine aminotransferase, mitochondrial | Ornithine aminotransferase, renal form | Ornithine delta-aminotransferase | Ornithine--oxo-acid aminotransferase
Type:
PROTEIN
Mol. Mass.:
48537.27
Organism:
Homo sapiens (Human)
Description:
ChEMBL_102740
Residue:
439
Sequence:
MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF
  
Inhibitor
Name:
BDBM50561615
Synonyms:
CHEMBL4747359
Type:
Small organic molecule
Emp. Form.:
C6H8FNO2
Mol. Mass.:
145.1316
SMILES:
N[C@H]1C=C(C[C@@H]1F)C(O)=O |r,c:2|
Structure:
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