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Target
Endothelin-1 receptor
Ligand
BDBM50124431
Substrate
n/a
Meas. Tech.
ChEBML_65494
IC50
19±n/a nM
Citation
 Boss, C; Bolli, MH; Weller, T; Fischli, W; Clozel, M Bis-sulfonamides as endothelin receptor antagonists. Bioorg Med Chem Lett 13:951-4 (2003) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50124431
Synonyms:
5-Isopropyl-pyridine-2-sulfonic acid [6-(2-ethanesulfonylamino-ethoxy)-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl]-amide | CHEMBL367958
Type:
Small organic molecule
Emp. Form.:
C27H36N6O8S2
Mol. Mass.:
636.74
SMILES:
CCS(=O)(=O)NCCOc1nc(nc(NS(=O)(=O)c2ccc(cn2)C(C)C)c1Oc1ccccc1OC)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: