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Target
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
Ligand
BDBM50561656
Substrate
n/a
Meas. Tech.
ChEMBL_2075685 (CHEMBL4731219)
IC50
640±n/a nM
Citation
 Thurairatnam, S; Lim, S; Barker, RH; Choi-Sledeski, YM; Hirth, BH; Jiang, J; Macor, JE; Makino, E; Maniar, S; Musick, K; Pribish, JR; Munson, M Brain Penetrable Inhibitors of Ceramide Galactosyltransferase for the Treatment of Lysosomal Storage Disorders. ACS Med Chem Lett 11:2010-2016 (2020) [PubMed]  Article 
Target
Name:
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
Synonyms:
2-hydroxyacylsphingosine 1-beta-galactosyltransferase | 2.4.1.47 | CGT | CGT_HUMAN | Ceramide UDP-galactosyltransferase | Cerebroside synthase | UDP-galactose-ceramide galactosyltransferase | UGT4 | UGT8
Type:
PROTEIN
Mol. Mass.:
61470.74
Organism:
Homo sapiens
Description:
ChEMBL_120191
Residue:
541
Sequence:
MKSYTPYFILLWSAVGIAKAAKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETIYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYHNGILNGKYKRNGHIKHEKKVK
  
Inhibitor
Name:
BDBM50561656
Synonyms:
CHEMBL4747085
Type:
Small organic molecule
Emp. Form.:
C21H26F3N5O2S
Mol. Mass.:
469.524
SMILES:
CC(C)NC(=O)CN1CCN(CC1)c1cc(c2scc(C(=O)N3CCC3)c2n1)C(F)(F)F
Structure:
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