Reaction Details Report a problem with these data
Target
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
Ligand
BDBM50561654
Substrate
n/a
Meas. Tech.
ChEMBL_2075740 (CHEMBL4731274)
IC50
0.200000±n/a nM
Citation
 Thurairatnam, S; Lim, S; Barker, RH; Choi-Sledeski, YM; Hirth, BH; Jiang, J; Macor, JE; Makino, E; Maniar, S; Musick, K; Pribish, JR; Munson, M Brain Penetrable Inhibitors of Ceramide Galactosyltransferase for the Treatment of Lysosomal Storage Disorders. ACS Med Chem Lett 11:2010-2016 (2020) [PubMed]  Article 
Target
Name:
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
Synonyms:
2-hydroxyacylsphingosine 1-beta-galactosyltransferase | 2.4.1.47 | CGT_MOUSE | Ceramide UDP-galactosyltransferase | Cerebroside synthase | Cgt | UDP-galactose-ceramide galactosyltransferase | Ugt4 | Ugt8 | Ugt8a
Type:
PROTEIN
Mol. Mass.:
61276.21
Organism:
Mus musculus
Description:
ChEMBL_120194
Residue:
541
Sequence:
MKSYTPYFMLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVLLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYTKNCDMMVGNQALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNFLERMKNTGVYLISRIGVSFLVLPKYERIMQKYNLLPAKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVSGAQEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGARHLRSAVHQISFCQYFLLDIAFVLLLGAVLLYFILSYVTKFIYRKIKSLWSKNEHSTVNGHYQNGIRNGKYKGNGRVKHEKKVR
  
Inhibitor
Name:
BDBM50561654
Synonyms:
CHEMBL4785914
Type:
Small organic molecule
Emp. Form.:
C20H22F6N4O4S
Mol. Mass.:
528.468
SMILES:
CNC(=O)c1csc2c(cc(nc12)N1CCC(CC1)OC(=O)N[C@@H](C)COC(F)(F)F)C(F)(F)F |r|
Structure:
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