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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50562070
Substrate
n/a
Meas. Tech.
ChEMBL_2077178 (CHEMBL4732969)
IC50
0.054000±n/a nM
Citation
 Kumari, S; Carmona, AV; Tiwari, AK; Trippier, PC Amide Bond Bioisosteres: Strategies, Synthesis, and Successes. J Med Chem 63:12290-12358 (2020) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50562070
Synonyms:
CHEMBL17612
Type:
Small organic molecule
Emp. Form.:
C40H53N5O5
Mol. Mass.:
683.8793
SMILES:
[H][C@](NC(=O)c1ccc2ccccc2n1)(C1CCOC1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN1C[C@@]2([H])CCCC[C@@]2([H])C[C@@]1([H])C(=O)NC(C)(C)C
Structure:
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