Reaction Details Report a problem with these data
Target
Melatonin receptor type 1B
Ligand
BDBM50125639
Substrate
n/a
Meas. Tech.
ChEBML_105255
IC50
3±n/a nM
Citation
 Mattson, RJ; Catt, JD; Keavy, D; Sloan, CP; Epperson, J; Gao, Q; Hodges, DB; Iben, L; Mahle, CD; Ryan, E; Yocca, FD Indanyl piperazines as melatonergic MT2 selective agents. Bioorg Med Chem Lett 13:1199-202 (2003) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50125639
Synonyms:
CHEMBL19339 | Cyclopropyl-[4-(6-methoxy-indan-1-yl)-piperazin-1-yl]-methanone
Type:
Small organic molecule
Emp. Form.:
C18H24N2O2
Mol. Mass.:
300.3954
SMILES:
COc1ccc2CCC(N3CCN(CC3)C(=O)C3CC3)c2c1
Structure:
Search PDB for entries with ligand similarity: