Reaction Details Report a problem with these data
Target
Microsomal triglyceride transfer protein large subunit
Ligand
BDBM50126214
Substrate
n/a
Meas. Tech.
ChEBML_123010
IC50
280±n/a nM
Citation
 Magnin, DR; Biller, SA; Wetterau, J; Robl, JA; Dickson, JK; Taunk, P; Harrity, TW; Lawrence, RM; Sun, CQ; Wang, T; Logan, J; Fryszman, O; Connolly, F; Jolibois, K; Kunselman, L Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents. Bioorg Med Chem Lett 13:1337-40 (2003) [PubMed]  Article 
Target
Name:
Microsomal triglyceride transfer protein large subunit
Synonyms:
MTP | MTP_BOVIN | MTTP
Type:
PROTEIN
Mol. Mass.:
99049.43
Organism:
Bos taurus
Description:
ChEMBL_123010
Residue:
887
Sequence:
FLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVFLDRGKGNLQDSVGYRISSNVDVALLWRSPDGDDNQLIQITMKDVNLENVNQQRGEKSIFKGKKSSQIIRKENLEAMQRPVLLHLIHGKIKEFYSYQNEPAAIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAHQDKVTKIKALDSCKIERAGFTTPHQVLGVTSKATSVTTYKIEDSFVVAVLSEEIRALRLNFLQSIAGKIVSRQKLELKTTEASVRLKPGKQVAAIIKAVDSKYTAIPIVGQVFQSKCKGCPSLSEHWQSIRKHLQPDNLSKAEAVRSFLAFIKHLRTAKKEEILQILKAENKEVLPQLVDAVTSAQTPDSLDAILDFLDFKSTESVILQERFLYACAFASHPDEELLRALISKFKGSFGSNDIRESVMIIIGALVRKLCQNQGCKLKGVIEAKKLILGGLEKAEKKEDIVMYLLALKNARLPEGIPLLLKYTETGEGPISHLAATTLQRYDVPFITDEVKKTMNRIYHQNRKIHEKTVRTTAAAIILKNNPSYMEVKNILLSIGELPKEMNKYMLSIVQDILRFETPASKMVRQVLKEMVAHNYDRFSKSGSSSAYTGYVERTSHSASTYSLDILYSGSGILRRSNLNIFQYIEKTPLHGIQVVIEAQGLEALIAATPDEGEENLDSYAGLSALLFDVQLRPVTFFNGYSDLMSKMLSASSDPMSVVKGLLLLIDHSQELQLQSGLKANMDVQGGLAIDITGAMEFSLWYRESKTRVKNRVSVLITGGITVDSSFVKAGLEIGAETEAGLEFISTVQFSQYPFLVCLQMDKEDVPYRQFETKYERLSTGRGYISRKRKESLIGGCEFPLHQENSDMCKVVFAPQPESSSSGWF
  
Inhibitor
Name:
BDBM50126214
Synonyms:
CHEMBL26721 | {4-[9-(2,2,2-Trifluoro-ethylcarbamoyl)-9H-fluoren-9-yl]-butyl}-phosphonic acid diisopropyl ester
Type:
Small organic molecule
Emp. Form.:
C26H33F3NO4P
Mol. Mass.:
511.5135
SMILES:
CC(C)OP(=O)(CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc12)OC(C)C
Structure:
Search PDB for entries with ligand similarity: