Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50011294
Substrate
n/a
Meas. Tech.
ChEMBL_2081576 (CHEMBL4737367)
Ki
19±n/a nM
Citation
 Renk, DR; Skraban, M; Bier, D; Schulze, A; Wabbals, E; Wedekind, F; Neumaier, F; Neumaier, B; Holschbach, M Design, synthesis and biological evaluation of Tozadenant analogues as adenosine A Eur J Med Chem 214:0 (2021) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_RAT | ADENOSINE A2a | Adenosine A2 receptor | Adenosine A2a receptor (A2a) | Adenosine Receptors A2a (A2a) | Adenosine receptor A2a and A3 | Adenosine receptors A2a | Adora2a | Rat striatal adenosine A2a receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45015.65
Organism:
Rattus norvegicus (rat)
Description:
Rat A2A receptors expressed in CHO cells.
Residue:
410
Sequence:
MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
  
Inhibitor
Name:
BDBM50011294
Synonyms:
A2A | Ro-4494351 | Ro-4494351-002 | Ro-4494351000 | SYN-115 | TOZADENANT
Type:
Small organic molecule
Emp. Form.:
C19H26N4O4S
Mol. Mass.:
406.499
SMILES:
COc1ccc(N2CCOCC2)c2sc(NC(=O)N3CCC(C)(O)CC3)nc12
Structure:
Search PDB for entries with ligand similarity: