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Target
Monoglyceride lipase
Ligand
BDBM50432829
Substrate
n/a
Meas. Tech.
ChEMBL_2084321 (CHEMBL4765584)
IC50
78±n/a nM
Citation
 Afzal, O; Akhtar, MS; Kumar, S; Ali, MR; Jaggi, M; Bawa, S Hit to lead optimization of a series of N-[4-(1,3-benzothiazol-2-yl)phenyl]acetamides as monoacylglycerol lipase inhibitors with potential anticancer activity. Eur J Med Chem 121:318-330 (2016) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50432829
Synonyms:
CHEMBL2171700
Type:
Small organic molecule
Emp. Form.:
C15H12N2O4
Mol. Mass.:
284.2668
SMILES:
COc1nn(-c2ccc(Oc3ccccc3)cc2)c(=O)o1
Structure:
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