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Target
Histamine H3 receptor
Ligand
BDBM50127845
Substrate
n/a
Meas. Tech.
ChEBML_83646
Ki
152±n/a nM
Citation
 Chai, W; Breitenbucher, JG; Kwok, A; Li, X; Wong, V; Carruthers, NI; Lovenberg, TW; Mazur, C; Wilson, SJ; Axe, FU; Jones, TK Non-imidazole heterocyclic histamine H3 receptor antagonists. Bioorg Med Chem Lett 13:1767-70 (2003) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50127845
Synonyms:
2-[2-Methyl-4-(3-piperidin-1-yl-propoxy)-phenyl]-indolizine | CHEMBL299223
Type:
Small organic molecule
Emp. Form.:
C23H28N2O
Mol. Mass.:
348.4812
SMILES:
Cc1cc(OCCCN2CCCCC2)ccc1-c1cc2ccccn2c1
Structure:
Search PDB for entries with ligand similarity: