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Target
Free fatty acid receptor 1
Ligand
BDBM50563844
Substrate
n/a
Meas. Tech.
ChEMBL_2085007 (CHEMBL4766270)
Ki
2.5±n/a nM
Citation
 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470). J Med Chem 59:10891-10916 (2016) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50563844
Synonyms:
CHEMBL4781604
Type:
Small organic molecule
Emp. Form.:
C34H35NO4
Mol. Mass.:
521.646
SMILES:
COc1cc(COc2ccc(cc2)[C@H](CC(O)=O)C#CC)ccc1CN1CCC2(CC1)C=Cc1ccccc21 |r,c:34|
Structure:
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