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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50564635
Substrate
n/a
Meas. Tech.
ChEMBL_2088472 (CHEMBL4769735)
IC50
9200±n/a nM
Citation
 Rodríguez-Lavado, J; Gallardo-Garrido, C; Mallea, M; Bustos, V; Osorio, R; Hödar-Salazar, M; Chung, H; Araya-Maturana, R; Lorca, M; Pessoa-Mahana, CD; Mella-Raipán, J; Saitz, C; Jaque, P; Reyes-Parada, M; Iturriaga-Vásquez, P; Pessoa-Mahana, H Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease. Eur J Med Chem 198:0 (2020) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50564635
Synonyms:
CHEMBL4795221
Type:
Small organic molecule
Emp. Form.:
C28H33BrFN5O2
Mol. Mass.:
570.496
SMILES:
Fc1ccc2[nH]cc(CCCN3CCN(CC3)C(=O)CN3CCN(CC3)C(=O)c3ccc(Br)cc3)c2c1
Structure:
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