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Target
Cyclin-dependent kinase 19
Ligand
BDBM50565105
Substrate
n/a
Meas. Tech.
ChEMBL_2090040 (CHEMBL4771303)
IC50
29±n/a nM
Citation
 Martínez-González, S; García, AB; Albarrán, MI; Cebriá, A; Amezquita-Alves, A; García-Campos, FJ; Martínez-Gago, J; Martínez-Torrecuadrada, J; Muñoz, IG; Blanco-Aparicio, C; Pastor, J Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors. Eur J Med Chem 201:0 (2020) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 19
Synonyms:
CDC2-related protein kinase 6 | CDC2L6 | CDK11 | CDK19 | CDK19_HUMAN | Cell division cycle 2-like protein kinase 6 | Cell division protein kinase 19 | Cyclin-dependent kinase 11 | Death-preventing kinase | KIAA1028
Type:
Serine/Threonine protein kinase
Mol. Mass.:
56816.68
Organism:
Homo sapiens (Human)
Description:
Q9BWU1
Residue:
502
Sequence:
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
  
Inhibitor
Name:
BDBM50565105
Synonyms:
CHEMBL4792974
Type:
Small organic molecule
Emp. Form.:
C25H15ClF3N5O3
Mol. Mass.:
525.867
SMILES:
FC(F)(F)c1cc(NC(=O)Nc2ccc3N(c4ccncc4)C(=O)c4cccnc4Oc3c2)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: