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Target
Retinoic acid receptor gamma
Ligand
BDBM50129724
Substrate
n/a
Meas. Tech.
ChEMBL_196008 (CHEMBL797872)
Ki
10000±n/a nM
Citation
 Michellys, PY; Ardecky, RJ; Chen, JH; Crombie, DL; Etgen, GJ; Faul, MM; Faulkner, AL; Grese, TA; Heyman, RA; Karanewsky, DS; Klausing, K; Leibowitz, MD; Liu, S; Mais, DA; Mapes, CM; Marschke, KB; Reifel-Miller, A; Ogilvie, KM; Rungta, D; Thompson, AW; Tyhonas, JS; Boehm, MF Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. J Med Chem 46:2683-96 (2003) [PubMed]  Article 
Target
Name:
Retinoic acid receptor gamma
Synonyms:
NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50345.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458016
Residue:
454
Sequence:
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
  
Inhibitor
Name:
BDBM50129724
Synonyms:
7-(3,5-Diisopropyl-2-propoxy-phenyl)-3-methyl-octa-2,4,6-trienoic acid | CHEMBL91779
Type:
Small organic molecule
Emp. Form.:
C24H34O3
Mol. Mass.:
370.525
SMILES:
CCCOc1c(cc(cc1\C(C)=C/C=C/C(/C)=C/C(O)=O)C(C)C)C(C)C
Structure:
Search PDB for entries with ligand similarity: