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Target
Gap junction beta-2 protein
Ligand
BDBM50565237
Substrate
n/a
Meas. Tech.
ChEMBL_2091062 (CHEMBL4772325)
IC50
17200±n/a nM
Citation
 Subedi, YP; Kjellgren, A; Roberts, P; Montgomery, H; Thackeray, N; Fiori, MC; Altenberg, GA; Chang, CT Amphiphilic aminoglycosides with increased selectivity for inhibition of connexin 43 (Cx43) hemichannels. Eur J Med Chem 203:0 (2020) [PubMed]  Article 
Target
Name:
Gap junction beta-2 protein
Synonyms:
CXB2_HUMAN | Connexin-26 | Cx26 | GJB2 | Gap junction beta-2 protein
Type:
PROTEIN
Mol. Mass.:
26226.37
Organism:
Homo sapiens
Description:
ChEMBL_117983
Residue:
226
Sequence:
MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRHEKKRKFIKGEIKSEFKDIEEIKTQKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDGFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYCSGKSKKPV
  
Inhibitor
Name:
BDBM50565237
Synonyms:
CHEMBL4776897
Type:
Small organic molecule
Emp. Form.:
C24H39ClN4O11
Mol. Mass.:
595.04
SMILES:
[H][C@]1(O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@@]3([H])O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)O[C@H](COc2ccc(Cl)cc2)[C@@H](O)[C@H](N)[C@H]1O |r|
Structure:
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