Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50130685
Substrate
n/a
Meas. Tech.
ChEMBL_152207 (CHEMBL758926)
EC50
18±n/a nM
Citation
 Chong, Y; Gumina, G; Mathew, JS; Schinazi, RF; Chu, CK l-2',3'-Didehydro-2',3'-dideoxy-3'-fluoronucleosides: synthesis, anti-HIV activity, chemical and enzymatic stability, and mechanism of resistance. J Med Chem 46:3245-56 (2003) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50130685
Synonyms:
(-)-4-Amino-5-fluoro-1-(4-fluoro-5-hydroxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidin-2-one | CHEMBL109896
Type:
Small organic molecule
Emp. Form.:
C9H9F2N3O3
Mol. Mass.:
245.1829
SMILES:
Nc1nc(=O)n(cc1F)[C@H]1OC(CO)C(F)=C1 |c:16|
Structure:
Search PDB for entries with ligand similarity: