Reaction Details
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Gastric inhibitory polypeptide receptor
Ligand
BDBM50566470
Substrate
n/a
Meas. Tech.
ChEMBL_2100503 (CHEMBL4808899)
IC50
125±n/a nM
Citation
Yang, B; Gelfanov, VM; Perez-Tilve, D; DuBois, B; Rohlfs, R; Levy, J; Douros, JD; Finan, B; Mayer, JP; DiMarchi, RD Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists. J Med Chem 64:4697-4708 (2021) [PubMed] Article More Info.:
Target
Name:
Gastric inhibitory polypeptide receptor
Synonyms:
GIP-R | GIPR_MOUSE | Gipr | Glucose-dependent insulinotropic polypeptide receptor
Type:
PROTEIN
Mol. Mass.:
53003.68
Organism:
Mus musculus
Description:
ChEMBL_120421
Residue:
460
Sequence:
MPLRLLLLLLWLWGLQWAETDSEGQTTTGELYQRWEHYGQECQKMLETTEPPSGLACNGSFDMYACWNYTAANTTARVSCPWYLPWFRQVSAGFVFRQCGSDGQWGSWRDHTQCENPEKNGAFQDQTLILERLQIMYTVGYSLSLTTLLLALLILSLFRRLHCTRNYIHMNLFTSFMLRAAAILTRDQLLPPLGPYTGDQAPTPWNQALAACRTAQIMTQYCVGANYTWLLVEGVYLHHLLVIVGRSEKGHFRCYLLLGWGAPALFVIPWVIVRYLRENTQCWERNEVKAIWWIIRTPILITILINFLIFIRILGILVSKLRTRQMRCPDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQVEGSLRFAKLAFEIFLSSFQGFLVSVLYCFINKEVQSEIRQGWRHRRLRLSLQEQRPRPHQELAPRAVPLSSACREAAVGNALPSGMLHVPGDEVLESYC
Inhibitor
Name:
BDBM50566470
Synonyms:
CHEMBL4857523
Type:
Small organic molecule
Emp. Form.:
C156H241N37O48S
Mol. Mass.:
3434.867
SMILES:
CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](O)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)C(O)=O)C(O)=O |r|
Structure:
