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Target
Atypical chemokine receptor 3
Ligand
BDBM50567153
Substrate
n/a
Meas. Tech.
ChEMBL_2102398 (CHEMBL4810794)
Ki
17±n/a nM
Citation
 Aspnes, GE; Menhaji-Klotz, E; Boehm, M; Londregan, AT; Lee, ECY; Limberakis, C; Coffey, SB; Brown, JA; Jones, RM; Hesp, KD Discovery and evaluation of non-basic small molecule modulators of the atypical chemokine receptor CXCR7. Bioorg Med Chem Lett 50:0 (2021) [PubMed]  Article 
Target
Name:
Atypical chemokine receptor 3
Synonyms:
ACKR3 | ACKR3_HUMAN | C-X-C chemokine receptor type 7 | C-X-C chemokine receptor type 7 (CXCR7) | CMKOR1 | CXC-R7 | CXCR-7 | CXCR7 | Chemokine orphan receptor 1 | G-protein coupled receptor 159 | G-protein coupled receptor RDC1 homolog | GPR159 | RDC-1 | RDC1
Type:
Enzyme
Mol. Mass.:
41498.84
Organism:
Homo sapiens (Human)
Description:
P25106
Residue:
362
Sequence:
MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQSTK
  
Inhibitor
Name:
BDBM50567153
Synonyms:
CHEMBL4855707
Type:
Small organic molecule
Emp. Form.:
C22H28N6O2
Mol. Mass.:
408.4967
SMILES:
[H][C@@]12CN(C[C@]1([H])[C@H]2C(=O)N[C@H]1CCN(C1)c1nccc2cccnc12)C(=O)N(C)CC |r|
Structure:
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