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Target
Carbonic anhydrase 12
Ligand
BDBM50567599
Substrate
n/a
Meas. Tech.
ChEMBL_2103537 (CHEMBL4812040)
Ki
7.9±n/a nM
Citation
 Elbadawi, MM; Eldehna, WM; Nocentini, A; Abo-Ashour, MF; Elkaeed, EB; Abdelgawad, MA; Alharbi, KS; Abdel-Aziz, HA; Supuran, CT; Gratteri, P; Al-Sanea, MM Identification of N-phenyl-2-(phenylsulfonyl)acetamides/propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities. Eur J Med Chem 218:0 (2021) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50567599
Synonyms:
CHEMBL4847847
Type:
Small organic molecule
Emp. Form.:
C16H18N2O5S2
Mol. Mass.:
382.455
SMILES:
CC(C(=O)Nc1ccc(cc1)S(N)(=O)=O)S(=O)(=O)c1ccc(C)cc1
Structure:
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