Reaction Details Report a problem with these data
Target
Cyclin-C
Ligand
BDBM50567859
Substrate
n/a
Meas. Tech.
ChEMBL_2103907 (CHEMBL4812410)
Ki
46±n/a nM
Citation
 Yu, M; Long, Y; Yang, Y; Li, M; Teo, T; Noll, B; Philip, S; Wang, S Discovery of a potent, highly selective, and orally bioavailable inhibitor of CDK8 through a structure-based optimisation. Eur J Med Chem 218:0 (2021) [PubMed]  Article 
Target
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM50567859
Synonyms:
CHEMBL4849792
Type:
Small organic molecule
Emp. Form.:
C27H36ClN5O3S
Mol. Mass.:
546.124
SMILES:
CC(C)(C)OC(=O)N1CCN(Cc2ccc(s2)-c2cncc(Cl)c2N2CCC3(CCNC3=O)CC2)CC1
Structure:
Search PDB for entries with ligand similarity: