Target
Retinoic acid receptor, gamma
Ligand
BDBM50133126
Substrate
n/a
Meas. Tech.
ChEMBL_196168 (CHEMBL705564)
Ki
>1000±n/a nM
Citation
 Michellys, PYArdecky, RJChen, JHD'Arrigo, JGrese, TAKaranewsky, DSLeibowitz, MDLiu, SMais, DAMapes, CMMontrose-Rafizadeh, COgilvie, KMReifel-Miller, ARungta, DThompson, AWTyhonas, JSBoehm, MF Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. J Med Chem 46:4087-103 (2003) [PubMed]  Article  BDB Entry
Target
Name:
Retinoic acid receptor, gamma
Synonyms:
Retinoic acid receptor gamma
Type:
PROTEIN
Mol. Mass.:
53686.83
Organism:
Rattus norvegicus
Description:
ChEMBL_196168
Residue:
485
Sequence:
MLALPLPPPGAGHCGGRRGNGLRVLGVLAPSFSPSRVAMYDCMESFVPGPRRLYGAAGPGAGLLRRATGSSCFAGLESFAWAQPASLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGPPDNYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSKPGPHPKASSEDEAPGSQGKRGQSPQPDQGP
  
Inhibitor
Name:
BDBM50133126
Synonyms:
5-[2-(3,5-Diisopropyl-2-propoxy-phenyl)-cyclopent-1-enyl]-3-methyl-penta-2,4-dienoic acid | CHEMBL133176
Type:
Small organic molecule
Emp. Form.:
C26H36O3
Mol. Mass.:
396.5622
SMILES:
CCCOc1c(cc(cc1C1=C(CCC1)\C=C\C(\C)=C\C(O)=O)C(C)C)C(C)C |t:11|
Structure:
Search PDB for entries with ligand similarity: