Reaction Details Report a problem with these data
Target
Lysine-specific histone demethylase 2
Ligand
BDBM50568521
Substrate
n/a
Meas. Tech.
ChEMBL_2105754 (CHEMBL4814429)
Ki
>250000±n/a nM
Citation
 Dai, XJ; Liu, Y; Xiong, XP; Xue, LP; Zheng, YC; Liu, HM Tranylcypromine Based Lysine-Specific Demethylase 1 Inhibitor: Summary and Perspective. J Med Chem 63:14197-14215 (2020) [PubMed]  Article 
Target
Name:
Lysine-specific histone demethylase 2
Synonyms:
AOF1 | C6orf193 | Flavin-containing amine oxidase domain-containing protein 1 | KDM1B | KDM1B_HUMAN | LSD2 | Lysine-specific histone demethylase 1B | Lysine-specific histone demethylase 2
Type:
PROTEIN
Mol. Mass.:
92112.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_992590
Residue:
822
Sequence:
MATPRGRTKKKASFDHSPDSLPLRSSGRQAKKKATETTDEDEDGGSEKKYRKCEKAGCTATCPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYTTWKKIWTSNGKTEPSPKAFMADQQLPYWVQCTKPECRKWRQLTKEIQLTPQIAKTYRCGMKPNTAIKPETSDHCSLPEDLRVLEVSNHWWYSMLILPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTNRAAATGNASPGKLEHSKAALSVHVPGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEYSRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKGLINTGVLSVGADQYLLPKDYHNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDKSFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQVLQFHLSNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
  
Inhibitor
Name:
BDBM50568521
Synonyms:
CHEMBL4878787
Type:
Small organic molecule
Emp. Form.:
C22H25F2N3O2
Mol. Mass.:
401.4496
SMILES:
N[C@H]1CCN(C1)C(=O)CNC1CC1c1cc(F)cc(F)c1OCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: