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Target
Lactoylglutathione lyase
Ligand
BDBM50569124
Substrate
n/a
Meas. Tech.
ChEMBL_2108109 (CHEMBL4816784)
IC50
5500±n/a nM
Citation
 Azuma, M; Inoue, M; Nishida, A; Akahane, H; Kitajima, M; Natani, S; Chimori, R; Yoshimori, A; Mano, Y; Uchiro, H; Tanuma, SI; Takasawa, R Addition of hydrophobic side chains improve the apoptosis inducibility of the human glyoxalase I inhibitor, TLSC702. Bioorg Med Chem Lett 40:0 (2021) [PubMed]  Article 
Target
Name:
Lactoylglutathione lyase
Synonyms:
Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase
Type:
Enzyme
Mol. Mass.:
20772.95
Organism:
Homo sapiens (Human)
Description:
Q04760
Residue:
184
Sequence:
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM
  
Inhibitor
Name:
BDBM50569124
Synonyms:
CHEMBL4877073
Type:
Small organic molecule
Emp. Form.:
C19H15NO5S
Mol. Mass.:
369.391
SMILES:
OC(=O)COc1ccc(\C=C(/CC(O)=O)c2nc3ccccc3s2)cc1
Structure:
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