Reaction Details Report a problem with these data
Target
Protein tyrosine phosphatase type IVA 3
Ligand
BDBM50323206
Substrate
n/a
Meas. Tech.
ChEMBL_2109173 (CHEMBL4817848)
IC50
46200±n/a nM
Citation
 Lin, L; Lu, L; Yuan, C; Wang, A; Zhu, M; Fu, X; Xing, S The dual inhibition against the activity and expression of tyrosine phosphatase PRL-3 from a rhodanine derivative. Bioorg Med Chem Lett 41:0 (2021) [PubMed]  Article 
Target
Name:
Protein tyrosine phosphatase type IVA 3
Synonyms:
PRL3 | PTP4A3 | Protein-tyrosine phosphatase 4A3 | TP4A3_HUMAN
Type:
PROTEIN
Mol. Mass.:
19546.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1461022
Residue:
173
Sequence:
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
  
Inhibitor
Name:
BDBM50323206
Synonyms:
CHEMBL208908 | sciadopitisin | sciadopitysin
Type:
Small organic molecule
Emp. Form.:
C33H24O10
Mol. Mass.:
580.5377
SMILES:
COc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3OC)-c3cc(O)c4c(cc(OC)cc4=O)o3)c2o1 |(10.61,-33.01,;9.27,-32.25,;7.94,-33.02,;7.94,-34.56,;6.61,-35.34,;5.28,-34.57,;5.27,-33.03,;6.6,-32.26,;3.95,-35.34,;3.95,-36.87,;2.63,-37.63,;2.63,-39.17,;1.31,-36.87,;-.03,-37.66,;-.03,-39.2,;-1.36,-36.89,;-1.36,-35.35,;-2.69,-34.58,;-.02,-34.58,;-.02,-33.04,;-1.36,-32.27,;-1.35,-30.73,;-.03,-29.96,;1.31,-30.73,;1.31,-32.27,;2.65,-33.04,;3.98,-32.27,;-2.68,-29.97,;-2.68,-28.42,;-4.03,-27.64,;-4.03,-26.1,;-5.36,-28.42,;-5.36,-29.97,;-6.7,-30.74,;-8.03,-29.97,;-9.37,-30.74,;-10.7,-29.97,;-8.03,-28.42,;-6.7,-27.64,;-6.7,-26.1,;-4.02,-30.74,;1.3,-35.35,;2.62,-34.57,)|
Structure:
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