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Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM572570
Substrate
n/a
Meas. Tech.
ChEMBL_2109463 (CHEMBL4818138)
EC50
23±n/a nM
Citation
 Pinkerton, AB; Sessions, EH; Hershberger, P; Maloney, PR; Peddibhotla, S; Hopf, M; Sergienko, E; Ma, CT; Smith, LH; Jackson, MR; Tanaka, J; Tsuji, T; Akiu, M; Cohen, SE; Nakamura, T; Gardell, SJ Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators. Bioorg Med Chem Lett 41:0 (2021) [PubMed]  Article 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM572570
Synonyms:
1-[4-(4-Chloro-benzenesulfonyl)-phenyl]-3-(1H-pyrazol-4-ylmethyl)-urea | BDBM50569539 | US11452717, Example 310
Type:
Small organic molecule
Emp. Form.:
C17H15ClN4O3S
Mol. Mass.:
390.844
SMILES:
Clc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)NCc2cn[nH]c2)cc1
Structure:
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