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Target
Polyphenol oxidase 2
Ligand
BDBM50569806
Substrate
n/a
Meas. Tech.
ChEMBL_2110407 (CHEMBL4819257)
Ki
70±n/a nM
Citation
 Ashooriha, M; Khoshneviszadeh, M; Khoshneviszadeh, M; Rafiei, A; Kardan, M; Yazdian-Robati, R; Emami, S Kojic acid-natural product conjugates as mushroom tyrosinase inhibitors. Eur J Med Chem 201:0 (2020) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50569806
Synonyms:
CHEMBL4865646
Type:
Small organic molecule
Emp. Form.:
C18H17N3O6
Mol. Mass.:
371.3441
SMILES:
COc1cc(ccc1OCc1cn(Cc2cc(=O)c(O)co2)nn1)C(C)=O
Structure:
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