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Target
Corticotropin-releasing factor receptor 2
Ligand
BDBM50135329
Substrate
n/a
Meas. Tech.
ChEMBL_51269 (CHEMBL665760)
EC50
42±n/a nM
Citation
 Dubowchik, GM; Michne, JA; Zuev, D; Schwartz, W; Scola, PM; James, CA; Ruediger, EH; Pin, SS; Burris, KD; Balanda, LA; Gao, Q; Wu, D; Fung, L; Fiedler, T; Browman, KE; Taber, MT; Zhang, J 2-arylaminothiazoles as high-affinity corticotropin-releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy. Bioorg Med Chem Lett 13:3997-4000 (2003) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 2
Synonyms:
CRF-R 2 | CRF2 | CRF2R | CRFR2_HUMAN | CRH-R 2 | CRH2R | CRHR2 | Corticotropin releasing factor receptor 2 | Corticotropin-releasing factor receptor 2 (CRF-2) | Corticotropin-releasing factor receptor 2/Corticotropin-releasing factor-binding protein | Corticotropin-releasing hormone receptor 2
Type:
Enzyme
Mol. Mass.:
47694.70
Organism:
Homo sapiens (Human)
Description:
Q13324
Residue:
411
Sequence:
MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
  
Inhibitor
Name:
BDBM50135329
Synonyms:
CHEMBL128100 | {5-[(Cyclopropylmethyl-propyl-amino)-methyl]-4-trifluoromethyl-thiazol-2-yl}-(2,4,6-trichloro-phenyl)-amine
Type:
Small organic molecule
Emp. Form.:
C18H19Cl3F3N3S
Mol. Mass.:
472.783
SMILES:
CCCN(CC1CC1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: