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Target
Glycogen phosphorylase, liver form
Ligand
BDBM50135562
Substrate
n/a
Meas. Tech.
ChEBML_70983
IC50
3±n/a nM
Citation
 Lu, Z; Bohn, J; Bergeron, R; Deng, Q; Ellsworth, KP; Geissler, WM; Harris, G; McCann, PE; McKeever, B; Myers, RW; Saperstein, R; Willoughby, CA; Yao, J; Chapman, K A new class of glycogen phosphorylase inhibitors. Bioorg Med Chem Lett 13:4125-8 (2003) [PubMed]  Article 
Target
Name:
Glycogen phosphorylase, liver form
Synonyms:
Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN
Type:
Homodimer
Mol. Mass.:
97153.98
Organism:
Homo sapiens (Human)
Description:
Dimers associate into a tetramer to form the enzymatically active phosphorylase A.
Residue:
847
Sequence:
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN
  
Inhibitor
Name:
BDBM50135562
Synonyms:
4-{2-[(4-Nitro-pyridine-2-carbonyl)-amino]-phenoxy}-phthalic acid | CHEMBL132191
Type:
Small organic molecule
Emp. Form.:
C20H13N3O8
Mol. Mass.:
423.3325
SMILES:
OC(=O)c1ccc(Oc2ccccc2NC(=O)c2cc(ccn2)[N+]([O-])=O)cc1C(O)=O
Structure:
Search PDB for entries with ligand similarity: