Reaction Details Report a problem with these data
Target
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50135599
Substrate
n/a
Meas. Tech.
ChEBML_208264
IC50
18.0±n/a nM
Citation
Hotoda, H; Furukawa, M; Daigo, M; Murayama, K; Kaneko, M; Muramatsu, Y; Ishii, MM; Miyakoshi, S; Takatsu, T; Inukai, M; Kakuta, M; Abe, T; Harasaki, T; Fukuoka, T; Utsui, Y; Ohya, S Synthesis and antimycobacterial activity of capuramycin analogues. Part 1: substitution of the azepan-2-one moiety of capuramycin. Bioorg Med Chem Lett 13:2829-32 (2003) [PubMed] Article
More Info.:
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_ECOLI | Phospho-N-acetylmuramoyl-pentapeptide-transferase/UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | mraY | murX
Type:
PROTEIN
Mol. Mass.:
39889.38
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_1454117
Residue:
360
Sequence:
MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRNDGPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKVVRKDTKGLIARWKYFWMSVIALGVAFALYLAGKDTPATQLVVPFFKDVMPQLGLFYILLAYFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR
Inhibitor
Name:
BDBM50135599
Synonyms:
(4S,5S,6S)-6-{(R)-Carbamoyl-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl]-methoxy}-4,5-dihydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid ((S)-2-oxo-azepan-3-yl)-amide | CHEMBL96695
Type:
Small organic molecule
Emp. Form.:
C23H31N5O12
Mol. Mass.:
569.5185
SMILES:
CO[C@H]1[C@@H](O)[C@@H](O[C@@H]1[C@@H](O[C@H]1OC(=C[C@H](O)[C@@H]1O)C(=O)N[C@H]1CCCCNC1=O)C(N)=O)n1ccc(=O)[nH]c1=O |c:13|