Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50571262
Substrate
n/a
Meas. Tech.
ChEMBL_2114176 (CHEMBL4823026)
Ki
1.000000±n/a nM
Citation
 Zhang, X; Zhu, B; Guo, L; Bakaj, I; Rankin, M; Ho, G; Kauffman, J; Lee, SP; Norquay, L; Macielag, M Optimization of physicochemical properties of pyridone-based EP3 receptor antagonists. Bioorg Med Chem Lett 47:0 (2021) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:
Enzyme
Mol. Mass.:
43335.03
Organism:
Homo sapiens (Human)
Description:
P43115
Residue:
390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
  
Inhibitor
Name:
BDBM50571262
Synonyms:
CHEMBL4858203
Type:
Small organic molecule
Emp. Form.:
C24H25FN2O2
Mol. Mass.:
392.4659
SMILES:
[H][C@]1(C[C@@H](C(C)C)c2ccc([nH]c2=O)-c2ccc3cccc(F)c3c2)CCNC1=O |r|
Structure:
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