Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM50137398
Substrate
n/a
Meas. Tech.
ChEBML_48367
Ki
1±n/a nM
Citation
Kim, TS; Hague, AB; Lee, TI; Lian, B; Tegley, CM; Wang, X; Burgess, TL; Qian, YX; Ross, S; Tagari, P; Lin, CH; Mayeda, C; Dao, J; Jordan, S; Mohr, C; Cheetham, J; Viswanadhan, V; Tasker, AS (4-Piperidinylphenyl)aminoethyl amides as a novel class of non-covalent cathepsin K inhibitors. Bioorg Med Chem Lett 14:87-90 (2003) [PubMed] Article
More Info.:
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Inhibitor
Name:
BDBM50137398
Synonyms:
((R)-2-(4-Hydroxy-phenyl)-1-{3-phenyl-1-[(4-piperidin-1-yl-phenylamino)-methyl]-propylcarbamoyl}-ethyl)-carbamic acid benzyl ester | CHEMBL169560
Type:
Small organic molecule
Emp. Form.:
C38H44N4O4
Mol. Mass.:
620.7804
SMILES:
Oc1ccc(C[C@@H](NC(=O)OCc2ccccc2)C(=O)N[C@@H](CCc2ccccc2)CNc2ccc(cc2)N2CCCCC2)cc1