Reaction Details Report a problem with these data
Target
Calpain small subunit 1
Ligand
BDBM50137939
Substrate
n/a
Meas. Tech.
ChEBML_43862
Ki
54±n/a nM
Citation
 Donkor, IO; Han, J; Zheng, X Design, synthesis, molecular modeling studies, and calpain inhibitory activity of novel alpha-ketoamides incorporating polar residues at the P1'-position. J Med Chem 47:72-9 (2003) [PubMed]  Article 
Target
Name:
Calpain small subunit 1
Synonyms:
CANP small subunit | CAPN4 | CAPNS1 | CDPS | CPNS1_PIG | CSS1 | Calcium-activated neutral proteinase small subunit | Calcium-dependent protease small subunit | Calcium-dependent protease small subunit 1 | Calpain regulatory subunit
Type:
PROTEIN
Mol. Mass.:
28062.13
Organism:
Sus scrofa
Description:
ChEMBL_43862
Residue:
266
Sequence:
MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS
  
Inhibitor
Name:
BDBM50137939
Synonyms:
CHEMBL366793 | {(S)-3-Methyl-1-[2-oxo-2-phenethylcarbamoyl-1-((S)-phenylmethyl)-ethylcarbamoyl]-butyl}-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C32H37N3O5
Mol. Mass.:
543.6533
SMILES:
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCCc1ccccc1
Structure:
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