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Target
Carbonic anhydrase 7
Ligand
BDBM50572415
Substrate
n/a
Meas. Tech.
ChEMBL_2116772 (CHEMBL4825838)
Ki
3.6±n/a nM
Citation
 Mishra, CB; Kumari, S; Angeli, A; Bua, S; Mongre, RK; Tiwari, M; Supuran, CT Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations. J Med Chem 64:3100-3114 (2021) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50572415
Synonyms:
CHEMBL4857705
Type:
Small organic molecule
Emp. Form.:
C16H19N3O4S
Mol. Mass.:
349.405
SMILES:
COc1ccc(NCC(=O)NCc2ccc(cc2)S(N)(=O)=O)cc1
Structure:
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