Reaction Details Report a problem with these data
Target
Squalene synthase
Ligand
BDBM50115109
Substrate
n/a
Meas. Tech.
ChEMBL_69826 (CHEMBL679575)
IC50
240±n/a nM
Citation
Ghosh, S; Chan, JM; Lea, CR; Meints, GA; Lewis, JC; Tovian, ZS; Flessner, RM; Loftus, TC; Bruchhaus, I; Kendrick, H; Croft, SL; Kemp, RG; Kobayashi, S; Nozaki, T; Oldfield, E Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. J Med Chem 47:175-87 (2003) [PubMed] Article
More Info.:
Target
Name:
Squalene synthase
Synonyms:
FDFT1 | FDFT_HUMAN | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48114.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1352847
Residue:
417
Sequence:
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
Inhibitor
Name:
BDBM50115109
Synonyms:
(5-chloropyridin-2-ylamino)methylenediphosphonic acid | CHEMBL54714 | [(5-Chloro-pyridin-2-ylamino)-phosphono-methyl]-phosphonic acid | [[(5-chloro-2-pyridinyl)amino]methylene]-1,1-bisphosphonate
Type:
Small organic molecule
Emp. Form.:
C6H9ClN2O6P2
Mol. Mass.:
302.546
SMILES:
OP(O)(=O)C(Nc1ccc(Cl)cn1)P(O)(O)=O