Reaction Details Report a problem with these data
Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50438487
Substrate
n/a
Meas. Tech.
ChEMBL_2117190 (CHEMBL4826256)
IC50
4940±n/a nM
Citation
Keough, DT; Wun, SJ; Baszczy?ski, O; Eng, WS; ?pa?ek, P; Panjikar, S; Naesens, L; Pohl, R; Rejman, D; Hocková, D; Ferrero, RL; Guddat, LW Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections. J Med Chem 64:5710-5729 (2021) [PubMed] Article
More Info.:
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA