Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50438487
Substrate
n/a
Meas. Tech.
ChEMBL_2117190 (CHEMBL4826256)
IC50
4940±n/a nM
Citation
 Keough, DTWun, SJBaszczy?ski, OEng, WS?pa?ek, PPanjikar, SNaesens, LPohl, RRejman, DHocková, DFerrero, RLGuddat, LW  Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections. J Med Chem 64:5710-5729 (2021) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
  
Inhibitor
Name:
BDBM50438487
Synonyms:
CHEMBL2414703
Type:
Small organic molecule
Emp. Form.:
C10H15N4O4P
Mol. Mass.:
286.2243
SMILES:
OP(O)(=O)CCCNCc1c[nH]c2c1nc[nH]c2=O
Structure:
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