Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50139107
Substrate
n/a
Meas. Tech.
ChEBML_144141
IC50
>10000±n/a nM
Citation
 Galiano, S; Erviti, O; Pérez, S; Moreno, A; Juanenea, L; Aldana, I; Monge, A Synthesis of new thiophene and benzo[b]thiophene hydrazide derivatives as human NPY Y(5) antagonists. Bioorg Med Chem Lett 14:597-9 (2004) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50139107
Synonyms:
CHEMBL157905 | Quinoline-8-sulfonic acid {4-[N'-(thiophene-2-carbonyl)-hydrazinocarbonyl]-cyclohexylmethyl}-amide
Type:
Small organic molecule
Emp. Form.:
C22H24N4O4S2
Mol. Mass.:
472.58
SMILES:
O=C(NNC(=O)c1cccs1)[C@H]1CC[C@H](CNS(=O)(=O)c2cccc3cccnc23)CC1 |wU:14.15,wD:11.11,(11.06,-8.14,;11.11,-6.61,;12.46,-5.88,;13.77,-6.68,;15.12,-5.96,;15.17,-4.42,;16.44,-6.77,;16.54,-8.29,;18.04,-8.66,;18.85,-7.35,;17.87,-6.19,;9.8,-5.79,;9.85,-4.25,;8.54,-3.44,;7.19,-4.16,;5.89,-3.34,;4.52,-4.07,;3.22,-3.25,;4.5,-2.04,;2.46,-1.75,;1.87,-3.97,;1.82,-5.51,;.47,-6.24,;-.86,-5.42,;-.81,-3.88,;-2.09,-3.06,;-2.04,-1.55,;-.69,-.82,;.61,-1.63,;.56,-3.16,;7.14,-5.7,;8.45,-6.51,)|
Structure:
Search PDB for entries with ligand similarity: