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Target
Peripheral plasma membrane protein CASK
Ligand
BDBM50574221
Substrate
n/a
Meas. Tech.
ChEMBL_2122080 (CHEMBL4831227)
IC50
1930±n/a nM
Citation
 Russ, N; Schröder, M; Berger, BT; Mandel, S; Aydogan, Y; Mauer, S; Pohl, C; Drewry, DH; Chaikuad, A; Müller, S; Knapp, S Design and Development of a Chemical Probe for Pseudokinase Ca J Med Chem 64:14358-14376 (2021) [PubMed]  Article 
Target
Name:
Peripheral plasma membrane protein CASK
Synonyms:
CASK | CSKP_HUMAN | Calcium/calmodulin-dependent serine protein kinase | LIN2 | Protein lin-2 homolog | hCASK
Type:
PROTEIN
Mol. Mass.:
105119.01
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774229
Residue:
926
Sequence:
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY
  
Inhibitor
Name:
BDBM50574221
Synonyms:
CHEMBL4847568
Type:
Small organic molecule
Emp. Form.:
C24H30Cl2N6O2
Mol. Mass.:
505.44
SMILES:
Clc1ccc(CNc2ncc(C(=O)NCCCN3CCCC3=O)c(NC3CCCC3)n2)c(Cl)c1
Structure:
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