Reaction Details Report a problem with these data
Target
1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Ligand
BDBM50141251
Substrate
n/a
Meas. Tech.
ChEBML_100169
IC50
50±n/a nM
Citation
 Gong, B; Hong, F; Kohm, C; Bonham, L; Klein, P Synthesis and SAR of 2-arylbenzoxazoles, benzothiazoles and benzimidazoles as inhibitors of lysophosphatidic acid acyltransferase-beta. Bioorg Med Chem Lett 14:1455-9 (2004) [PubMed]  Article 
Target
Name:
1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Synonyms:
1-acylglycerol-3-phosphate O-acyltransferase beta | AGPAT2 | PLCB_HUMAN
Type:
PROTEIN
Mol. Mass.:
30924.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_321473
Residue:
278
Sequence:
MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ
  
Inhibitor
Name:
BDBM50141251
Synonyms:
(3-Benzooxazol-2-yl-4-chloro-phenyl)-carbamic acid prop-2-ynyl ester | CHEMBL35165
Type:
Small organic molecule
Emp. Form.:
C17H11ClN2O3
Mol. Mass.:
326.734
SMILES:
Clc1ccc(NC(=O)OCC#C)cc1-c1nc2ccccc2o1
Structure:
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