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Target
Peptide deformylase
Ligand
BDBM50141385
Substrate
n/a
Meas. Tech.
ChEBML_144950
IC50
50±n/a nM
Citation
 Molteni, V; He, X; Nabakka, J; Yang, K; Kreusch, A; Gordon, P; Bursulaya, B; Warner, I; Shin, T; Biorac, T; Ryder, NS; Goldberg, R; Doughty, J; He, Y Identification of novel potent bicyclic peptide deformylase inhibitors. Bioorg Med Chem Lett 14:1477-81 (2004) [PubMed]  Article 
Target
Name:
Peptide deformylase
Synonyms:
DEF_STAAU | PDF | Peptide Deformylase | Polypeptide deformylase | def | def1 | pdf1
Type:
PROTEIN
Mol. Mass.:
20556.80
Organism:
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Description:
ChEMBL_459563
Residue:
183
Sequence:
MLTMKDIIRDGHPTLRQKAAELELPLTKEEKETLIAMREFLVNSQDEEIAKRYGLRSGVGLAAPQINISKRMIAVLIPDDGSGKSYDYMLVNPKIVSHSVQEAYLPTGEGCLSVDDNVAGLVHRHNRITIKAKDIEGNDIQLRLKGYPAIVFQHEIDHLNGVMFYDHIDKNHPLQPHTDAVEV
  
Inhibitor
Name:
BDBM50141385
Synonyms:
2-[4-(3,3-Dimethyl-2-oxo-butyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-2-yl]-N-hydroxy-acetamide | CHEMBL35361
Type:
Small organic molecule
Emp. Form.:
C16H20N2O4S
Mol. Mass.:
336.406
SMILES:
CC(C)(C)C(=O)CN1C(=O)C(CC(=O)NO)Sc2ccccc12
Structure:
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