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Target
Melatonin receptor type 1A
Ligand
BDBM463447
Substrate
n/a
Meas. Tech.
ChEMBL_2125495 (CHEMBL4834840)
EC50
0.063000±n/a nM
Citation
 Ferreira, MA; Azevedo, H; Mascarello, A; Segretti, ND; Russo, E; Russo, V; Guimarães, CRW Discovery of  J Med Chem 64:1904-1929 (2021) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1A
Synonyms:
MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:
Enzyme
Mol. Mass.:
39392.94
Organism:
Homo sapiens (Human)
Description:
P48039
Residue:
350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
  
Inhibitor
Name:
BDBM463447
Synonyms:
US10781182, Compound IA2-143 | US11091445, Compound code IA2-143
Type:
Small organic molecule
Emp. Form.:
C13H16ClN3O3
Mol. Mass.:
297.737
SMILES:
COc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O
Structure:
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