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Target
Retinoic acid receptor RXR-beta
Ligand
BDBM50575870
Substrate
n/a
Meas. Tech.
ChEMBL_2126071 (CHEMBL4835416)
EC50
130±n/a nM
Citation
 Schierle, S; Chaikuad, A; Lillich, FF; Ni, X; Woltersdorf, S; Schallmayer, E; Renelt, B; Ronchetti, R; Knapp, S; Proschak, E; Merk, D Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics. J Med Chem 64:5123-5136 (2021) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-beta
Synonyms:
NR2B2 | Nuclear receptor subfamily 2 group B member 2 | RXRB | RXRB_HUMAN | Retinoic acid receptor RXR-beta | Retinoid X receptor beta | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
56932.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_39045
Residue:
533
Sequence:
MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQTPEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
  
Inhibitor
Name:
BDBM50575870
Synonyms:
CHEMBL4854458
Type:
Small organic molecule
Emp. Form.:
C26H31NO3
Mol. Mass.:
405.5292
SMILES:
CC(C)(C)c1cc(cc(c1)C(C)(C)C)-c1oc(CCC(O)=O)nc1-c1ccccc1
Structure:
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