Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM50576019
Substrate
n/a
Meas. Tech.
ChEMBL_2126195 (CHEMBL4835540)
IC50
7.0±n/a nM
Citation
 Konteatis, ZTravins, JGross, SMarjon, KBarnett, AMandley, ENicolay, BNagaraja, RChen, YSun, YLiu, ZYu, JYe, ZJiang, FWei, WFang, CGao, YKalev, PHyer, MLDeLaBarre, BJin, LPadyana, AKDang, LMurtie, JBiller, SASui, ZMarks, KM Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous  J Med Chem 64:4430-4449 (2021) [PubMed]  Article 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM50576019
Synonyms:
CHEMBL4568226
Type:
Small organic molecule
Emp. Form.:
C30H23N5O2
Mol. Mass.:
485.5359
SMILES:
COc1ccc(cc1)-c1c(Nc2ccccn2)[nH]c2c(c(nn2c1=O)-c1ccccc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: