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Target
Immunoglobulin lambda variable 6-57
Ligand
BDBM50078833
Substrate
n/a
Meas. Tech.
ChEMBL_2126711 (CHEMBL4836056)
EC50
6880±n/a nM
Citation
 Yan, NL; Santos-Martins, D; Nair, R; Chu, A; Wilson, IA; Johnson, KA; Forli, S; Morgan, GJ; Petrassi, HM; Kelly, JW Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design. J Med Chem 64:6273-6299 (2021) [PubMed]  Article 
Target
Name:
Immunoglobulin lambda variable 6-57
Synonyms:
IGLV6-57 | Ig lambda chain V-VI region AR | Ig lambda chain V-VI region EB4 | Ig lambda chain V-VI region NIG-48 | Ig lambda chain V-VI region SUT | Ig lambda chain V-VI region WLT | Immunoglobulin lambda variable 6-57 | LV657_HUMAN
Type:
PROTEIN
Mol. Mass.:
12561.55
Organism:
Homo sapiens
Description:
ChEMBL_120180
Residue:
117
Sequence:
MAWAPLLLTLLAHCTGSWANFMLTQPHSVSESPGKTVTISCTGSSGSIASNYVQWYQQRPGSAPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSN
  
Inhibitor
Name:
BDBM50078833
Synonyms:
4-Methyl-7-(diethylamino)coumarin | 7-(diethylamino)-4-methyl-2H-chromen-2-one | CHEMBL315348 | Coumarin 1 | Coumarin 47 | coumarin 460
Type:
Small organic molecule
Emp. Form.:
C14H17NO2
Mol. Mass.:
231.2903
SMILES:
CCN(CC)c1ccc2c(C)cc(=O)oc2c1
Structure:
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