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Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM50576692
Substrate
n/a
Meas. Tech.
ChEMBL_2127690 (CHEMBL4837035)
Ki
11000±n/a nM
Citation
 Zhou, Y; Shen, W; Peng, J; Deng, Y; Li, X Identification of isoform/domain-selective fragments from the selection of DNA-encoded dynamic library. Bioorg Med Chem 45:0 (2021) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM50576692
Synonyms:
CHEMBL4872768
Type:
Small organic molecule
Emp. Form.:
C32H40FN5O7
Mol. Mass.:
625.6877
SMILES:
COc1cc(CC(=O)NCCCNC(=O)c2cn3C(C)COc4c(N5CCN(C)CC5)c(F)cc(c34)c2=O)cc(OC)c1OC
Structure:
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