Reaction Details Report a problem with these data
Target
Metabotropic glutamate receptor 3
Ligand
BDBM50576813
Substrate
n/a
Meas. Tech.
ChEMBL_2127827 (CHEMBL4837172)
EC50
130±n/a nM
Citation
 Yamada, Y; Gilliland, K; Xiang, Z; Haymer, D; Crocker, KE; Loch, MT; Schulte, ML; Rodriguez, AL; Niswender, CM; Jeffrey Conn, P; Lindsley, CW; Melancon, BJ Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds. Bioorg Med Chem Lett 50:0 (2021) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 3
Synonyms:
GRM3_RAT | Gprc1c | Grm3 | Mglur3 | glutamate receptor, metabotropic 3 precursor
Type:
Protein
Mol. Mass.:
98971.84
Organism:
Rattus norvegicus (Rat)
Description:
P31422
Residue:
879
Sequence:
MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL
  
Inhibitor
Name:
BDBM50576813
Synonyms:
CHEMBL4846460
Type:
Small organic molecule
Emp. Form.:
C24H29ClO6
Mol. Mass.:
448.936
SMILES:
Cc1c(O)c(ccc1OCCCCOc1ccc(Cl)c(c1)C(O)=O)C(=O)CC(C)(C)C
Structure:
Search PDB for entries with ligand similarity: