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Target
RNA-directed RNA polymerase catalytic subunit
Ligand
BDBM50577041
Substrate
n/a
Meas. Tech.
ChEMBL_2128787 (CHEMBL4838216)
EC50
21000±n/a nM
Citation
 Pismataro, MC; Felicetti, T; Bertagnin, C; Nizi, MG; Bonomini, A; Barreca, ML; Cecchetti, V; Jochmans, D; De Jonghe, S; Neyts, J; Loregian, A; Tabarrini, O; Massari, S 1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors. Eur J Med Chem 221:0 (2021) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase catalytic subunit
Synonyms:
2.7.7.48 | PB1 | RDRP_I34A1
Type:
PROTEIN
Mol. Mass.:
86603.70
Organism:
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
Description:
ChEMBL_119393
Residue:
757
Sequence:
MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCIETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMKKEEMGITTHFQRKRRVRDNMTKKMITQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYMTRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNDSTRKKIEKIRPLLIEGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESMNNAVMMPAHGPAKNMEYDAVATTHSWIPKRNRSILNTSQRGVLEDEQMYQRCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFTEIMKICSTIEELRRQK
  
Inhibitor
Name:
BDBM50577041
Synonyms:
CHEMBL4870823
Type:
Small organic molecule
Emp. Form.:
C20H13N5O2
Mol. Mass.:
355.3495
SMILES:
Cc1cc(-c2ccccc2)n2nc(nc2n1)-c1nc2ccccc2c(=O)o1
Structure:
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